2. Academic Validation
  3. Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia

Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia

  • J Nat Prod. 2014 Oct 24;77(10):2248-54. doi: 10.1021/np500509q.
Man-Man Li 1,  Xiao-Qin Su,  Jing Sun,  Yu-Fan Gu,  Zheng Huang,  Ke-Wu Zeng,  Qian Zhang,  Yun-Fang Zhao,  Daneel Ferreira,  Jordan K Zjawiony,  Jun Li,  Peng-Fei Tu
Affiliations

Affiliation

  • 1 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
PMID: 25245917 DOI: 10.1021/np500509q
Abstract

Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triterpenoids, 7-14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural Pentacyclic Triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9-40.5 μM.

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