2. Academic Validation
  3. Halenaquinone inhibits RANKL-induced osteoclastogenesis

Halenaquinone inhibits RANKL-induced osteoclastogenesis

  • Bioorg Med Chem Lett. 2014 Nov 15;24(22):5315-7. doi: 10.1016/j.bmcl.2014.09.043.
Sachiko Tsukamoto 1,  Tomoharu Takeuchi 2,  Tetsuro Kawabata 3,  Hikaru Kato 3,  Michiko Yamakuma 3,  Kanae Matsuo 3,  Ahmed H El-Desoky 3,  Fitje Losung 4,  Remy E P Mangindaan 4,  Nicole J de Voogd 5,  Yoichiro Arata 2,  Hideyoshi Yokosawa 6
Affiliations

Affiliations

  • 1 Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address: sachiko@kumamoto-u.ac.jp.
  • 2 Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
  • 3 Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • 4 Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • 5 Naturalis Biodiversity Center, PO Box 9517, 2300 RA Leiden, The Netherlands.
  • 6 School of Pharmacy, Aichi Gakuin University, Chikusa-ku, Nagoya 464-8650, Japan.
PMID: 25278237 DOI: 10.1016/j.bmcl.2014.09.043
Abstract

Halenaquinone was isolated from the marine Sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant Acid Phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.

Keywords

Halenaquinone; Marine sponge; Osteoclastogenesis; Petrosia alfiani.

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