2. Academic Validation
  3. Inhibitors of c-Jun N-terminal kinases: an update

Inhibitors of c-Jun N-terminal kinases: an update

  • J Med Chem. 2015 Jan 8;58(1):72-95. doi: 10.1021/jm501212r.
Pierre Koch 1,  Matthias Gehringer,  Stefan A Laufer
Affiliations

Affiliation

  • 1 Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
PMID: 25415535 DOI: 10.1021/jm501212r
Abstract

The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus Other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.

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