2. Academic Validation
  3. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts

The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts

  • Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9. doi: 10.1016/j.bbrc.2014.11.006.
Kumiko Gotoh 1,  Ryusho Kariya 2,  Md Masud Alam 2,  Kouki Matsuda 2,  Shinichiro Hattori 2,  Yuki Maeda 3,  Keiichi Motoyama 3,  Akihiro Kojima 4,  Hidetoshi Arima 3,  Seiji Okada 5
Affiliations

Affiliations

  • 1 Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan; Radioisotope Center, Institute of Resource Development and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.
  • 2 Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
  • 3 Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
  • 4 Radioisotope Center, Institute of Resource Development and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.
  • 5 Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan. Electronic address: okadas@kumamoto-u.ac.jp.
PMID: 25446086 DOI: 10.1016/j.bbrc.2014.11.006
Abstract

Primary effusion lymphoma (PEL) is a subtype of aggressive and chemotherapy-resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of methyl-β-cyclodextrin (M-β-CyD) in vitro and in vivo. M-β-CyD quickly induced caspase-dependent Apoptosis in PEL cells via Cholesterol depletion from the plasma membrane. In a PEL xenograft mouse model, M-β-CyD significantly inhibited the growth and invasion of PEL cells without apparent adverse effects. These results strongly suggest that M-β-CyD has the potential to be an effective antitumor agent against PEL.

Keywords

Apoptosis; Cholesterol; Methyl-β-cyclodextrin; Mice model; Plasma membrane; Primary effusion lymphoma.

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