1. Academic Validation
  2. Design, synthesis and structure--activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

Design, synthesis and structure--activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

  • Eur J Med Chem. 2015 Jan 7:89:21-31. doi: 10.1016/j.ejmech.2014.10.037.
Ayyiliath M Sajith 1 K K Abdul Khader 2 Nithin Joshi 3 Manchala Nageswar Reddy 4 M Syed Ali Padusha 2 H P Nagaswarupa 5 M Nibin Joy 6 Yadav D Bodke 6 Ranjith P Karuvalam 7 Rinti Banerjee 3 A Muralidharan 8 P Rajendra 4
Affiliations

Affiliations

  • 1 Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India. Electronic address: sajith.chem@gmail.com.
  • 2 Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India.
  • 3 Department of Biosciences and Bioengineering, IIT Mumbai, India.
  • 4 Central University of Kerala, Vidyanagar, Kasaragod, Periya, Kerala, India.
  • 5 Research Center, Department of Chemistry, East West Institute of Technology, Bangalore, India.
  • 6 Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, India.
  • 7 School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. Kannur, Kerala, India.
  • 8 Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India.
Abstract

Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR Cancer cell lines. Regio-isomeric imidazo[4,5-b]pyridine analogues were synthesized and evaluated for their cytotoxic activity against a range of Cancer cell lines. The structure-activity relationship (SAR) studies of the imidazopyridine analogues are also described. Analogue 6b displayed strong cytotoxicity and good microsomal stability.

Keywords

Chemotherapy; Cytotoxic studies; Imidazo[4,5-b]pyridine analogues; Suzuki coupling.

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