2. Academic Validation
  3. Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4

Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4

  • Bioorg Med Chem Lett. 2015 Jan 1;25(1):117-21. doi: 10.1016/j.bmcl.2014.10.090.
James McNulty 1,  Sean van den Berg,  Dennis Ma,  Daniel Tarade,  Seema Joshi,  Julia Church
Affiliations

Affiliation

  • 1 Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ont. L8S 4M1, Canada.
PMID: 25466200 DOI: 10.1016/j.bmcl.2014.10.090
Abstract

Two substituted biaryl analogues of colchicine and combretastatin A4, readily available through a one-step, protecting group free Suzuki-Miyaura reaction were discovered to exhibit Anticancer activity while simultaneously being of low cytotoxicity to noncancerous cell lines. The compounds were shown to initiate Apoptosis selectively via a mechanism involving inhibition of tubulin polymerization.

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