1. Academic Validation
  2. Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats

Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats

  • Int J Neurosci. 2016;126(1):70-5. doi: 10.3109/00207454.2014.991821.
Yigit Uyanikgil 1 2 Kübra Özkeşkek 3 Türker Çavuşoğlu 1 2 Volkan Solmaz 4 Mehmet Kemal Tümer 5 Oytun Erbas 6
Affiliations

Affiliations

  • 1 a Department of Histology &Embryology, Ege University School of Medicine, Izmir, Turkey.
  • 2 b Cord blood, Cell and Tissue Research and Application Center, Ege University, Izmir, Turkey.
  • 3 c Department of Neurology, Yozgat State Hospital, Yozgat, Turkey.
  • 4 d Department of Neurology, Turhal State Hospital, Turhal, Tokat, Turkey.
  • 5 e Department of Oral and Maxillofacial Surgery, Gaziosmanpasa University Faculty of Dentistry, Tokat, Turkey.
  • 6 f Department of Physiology, Gaziosmanpasa University Medical Faculty, Tokat, Turkey.
Abstract

Aims: Many drugs have been associated with seizures as a side effect. Although they are defined as safe for nervous system. The effect on proconvulsant activity of beta lactam Antibiotics have been also reported. We aimed to investigate whether ceftriaxone has an anticonvulsant effect on PTZ-induced seizures in rats.

Materials and methods: 36 male Sprague-Dawley rats, 18 of them for EEG recording and 18 of them are for behavioral studies, were randomly divided in two groups: group A for EEG recordings and group B for behavioral assesment. About 70 mg/kg PTZ was used for behavioral studies after Ceftriaxone administiration. About 35 mg/kg PTZ were used for EEG recording after ceftriaxone administiration. The electrodes were implanted on dura over the left frontal cortex and the reference electrode was implanted over the cerebellum for EEG recording. The Racine convulsion scale, first myoclonic jerk onset time, spike percentages, brain MDA and SOD levels were evaluated between the groups.

Results: First myoclonic jerk onset time was significantly shorter in saline group than both 200 and 400 mg/kg ceftriaxone groups (p < 0.05). Racine's convulsion scale was significantly lower in 200 and 400 mg/kg ceftriaxone groups than saline group (p < 0.01, p < 0.0001). Both of two ceftriaxone groups have lower spike percentages than the saline group (p < 0.05). Significantly lower MDA levels and higher SOD activity were determined in 200 mg/kg ceftriaxone group compared with the saline group (p < 0.05).

Conclusion: Our study demonstrated that ceftriaxone has protective effects on PTZ-induced convulsions and on oxidative damage associated with PTZ.

Keywords

ceftriaxone; malondialdehyde; pentylenetetrazol; superoxide dismutase.

Figures
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验,部分功能也使用 Cookies 帮助我们更好地理解您的需求,为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问,请阅读我们的《隐私声明》