Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia

Affiliations

• 1 Departments of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
• 2 Division of Pediatric Hematology and Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
• 3 Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
• 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
• 5 Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10065, USA; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan.
• 6 Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
• 7 MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
• 8 Departments of Medicine and Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
• 9 Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
• 10 Hôpital Maisonneuve-Rosemont, Montreal, QC H1T 2M4, Canada.
• 11 Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
• 12 Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
• 13 Division of Pediatric Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
• 14 Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell & Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA.
• 15 Pediatric Hematology-Oncology, University of California, San Francisco, San Francisco, CA 94143, USA.
• 16 Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10065, USA.
• 17 Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Howard Hughes Medical Institute, Portland, OR 97239, USA.
• 18 Departments of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: markus.muschen@ucsf.edu.