2. Academic Validation
  3. Cytotoxic and antioxidant constituents from the leaves of Psidium guajava

Cytotoxic and antioxidant constituents from the leaves of Psidium guajava

  • Bioorg Med Chem Lett. 2015;25(10):2193-8. doi: 10.1016/j.bmcl.2015.03.058.
Xiao-He Feng 1,  Zi-Hao Wang 1,  Da-Li Meng 2,  Xian Li 1
Affiliations

Affiliations

  • 1 Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
  • 2 Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. Electronic address: mengdl@163.com.
PMID: 25862199 DOI: 10.1016/j.bmcl.2015.03.058
Abstract

Psidium guajava (Myrtaceae) is an evergreen shrub growing extensively throughout the tropical and subtropical areas. Four new compounds, guavinoside C, D, E and F (1-3, 10) were isolated from the leaves of P. guajava, along with six known ones (4-9). Their structures were elucidated by spectroscopic analysis. Compounds 1, 4 and 10 showed significant cytotoxic activities on HeLa, SGC-7901 and A549 cell lines, respectively. Compounds 1 and 4-10 showed antioxidant activities in DPPH, ABTS and FRAP assays, and five of them (1, 4-6, 10) exhibited stronger activities than that of vitamin C.

Keywords

Antioxidant activities; Benzophenone glycosides; Cytotoxic activities; Polyphenols; Psidium guajava.

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