2. Academic Validation
  3. Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata

Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata

  • Planta Med. 2015 Aug;81(12-13):1128-32. doi: 10.1055/s-0035-1546036.
Qingxi Su 1,  Priscilla Krai 2,  Michael Goetz 3,  Maria B Cassera 2,  David G I Kingston 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
  • 2 Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
  • 3 Natural Products Discovery Institute, Doylestown, Pennsylvania, United States.
PMID: 26018916 DOI: 10.1055/s-0035-1546036
Abstract

Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.

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