2. Academic Validation
  3. New Griselimycins for Treatment of Tuberculosis

New Griselimycins for Treatment of Tuberculosis

  • Chem Biol. 2015 Aug 20;22(8):981-2. doi: 10.1016/j.chembiol.2015.08.002.
Ulrike Holzgrabe 1
Affiliations

Affiliation

  • 1 Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: ulrike.holzgrabe@pharmazie.uni-wuerzburg.de.
PMID: 26295835 DOI: 10.1016/j.chembiol.2015.08.002
Abstract

Griselimycin (GM), a natural product isolated a half century ago, is having a bit of a renaissance. After being known for more than 50 years, it is now being pursued as a treatment for tuberculosis. With the new mechanism of action, excellent in vitro and in vivo activity against sensitive and drug-resistant Mycobacterium tuberculosis, and the improved pharmacokinetic properties, the cyclohexyl derivative of GM demonstrates a high translational potential.

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