2. Academic Validation
  3. Suppressors of superoxide production from mitochondrial complex III

Suppressors of superoxide production from mitochondrial complex III

  • Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910.
Adam L Orr 1,  Leonardo Vargas 2,  Carolina N Turk 2,  Janine E Baaten 2,  Jason T Matzen 2,  Victoria J Dardov 2,  Stephen J Attle 2,  Jing Li 2,  Douglas C Quackenbush 2,  Renata L S Goncalves 1,  Irina V Perevoshchikova 1,  H Michael Petrassi 2,  Shelly L Meeusen 2,  Edward K Ainscow 2,  Martin D Brand 1
Affiliations

Affiliations

  • 1 Buck Institute for Research on Aging, Novato, California, USA.
  • 2 Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
PMID: 26368590 DOI: 10.1038/nchembio.1910
Abstract

Mitochondrial electron transport drives ATP synthesis but also generates Reactive Oxygen Species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.

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