2. Academic Validation
  3. Syntheses and biological evaluation of C-3'-N-acyl modified taxane analogues from 1-deoxybaccatin-VI

Syntheses and biological evaluation of C-3'-N-acyl modified taxane analogues from 1-deoxybaccatin-VI

  • Eur J Med Chem. 2015 Nov 2:104:97-105. doi: 10.1016/j.ejmech.2015.09.019.
Qing-Feng Li 1,  Hai-Xia Lin 2,  Yong-Mei Cui 1,  Pei-Pei Xu 1
Affiliations

Affiliations

  • 1 Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Road, Baoshan District, Shanghai 200444, China.
  • 2 Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Road, Baoshan District, Shanghai 200444, China. Electronic address: haixialin@staff.shu.edu.cn.
PMID: 26448037 DOI: 10.1016/j.ejmech.2015.09.019
Abstract

A series of side-chain modified taxane analogues were synthesized and their in vitro Anticancer activities against four human Cancer cell lines: MDA-MB-231 (human breast Cancer), PC-3 (human prostatic Cancer), HepG2 and H460 (human hepatoma) were studied. The three hydroxyl groups at C-7, C-9 and C-10 enable the behavior of these compounds to be evidently distinct from Other similar compounds. The strong cytotoxicity in the four cell lines showed by the newly synthesized taxane analogues 13a and 13d indicated them as potential lead compounds for Anticancer drug design.

Keywords

In vitro anticancer activity; MDA-MB-231; PC-3 and HepG2 and H460 cell lines; Paclitaxel; Taxane analogues.

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