2. Academic Validation
  3. Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

  • J Org Chem. 2015 Dec 18;80(24):12501-8. doi: 10.1021/acs.joc.5b02367.
Zhuo Shang 1,  Angela A Salim 1,  Zeinab Khalil 1,  Michelle Quezada 1,  Paul V Bernhardt 1,  Robert J Capon 1
Affiliations

Affiliation

  • 1 Institute for Molecular Bioscience and ‡School of Chemistry and Molecular Biosciences, The University of Queensland , St. Lucia, Queensland 4072, Australia.
PMID: 26605854 DOI: 10.1021/acs.joc.5b02367
Abstract

Viridicatumtoxins, which belong to a rare class of Fungal tetracycline-like mycotoxins, were subjected to comprehensive spectroscopic and chemical analysis, leading to reassignment/assignment of absolute configurations and characterization of a remarkably acid-stable Antibiotic scaffold. Structure activity relationship studies revealed exceptional growth inhibitory activity against vancomycin-resistant Enterococci (IC50 40 nM), >270-fold more potent than the commercial Antibiotic oxytetracycline.

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