2. Academic Validation
  3. Gambogic acid induces apoptotic cell death in T98G glioma cells

Gambogic acid induces apoptotic cell death in T98G glioma cells

  • Bioorg Med Chem Lett. 2016 Feb 1;26(3):1097-1101. doi: 10.1016/j.bmcl.2015.11.043.
Mya Thida 1,  Dae Won Kim 2,  Thi Thu Thuy Tran 3,  Minh Quan Pham 3,  Heesu Lee 4,  Inki Kim 5,  Jae Wook Lee 6
Affiliations

Affiliations

  • 1 Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea.
  • 2 Department of Biochemistry and Molecular Biology, Research Institute of Oral Science, College of Dentistry, Gangneung Wonju National University, Gangneung 210-702, Republic of Korea.
  • 3 Institute of Natural Products Research, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Cay Giay, Hanoi, Viet Nam.
  • 4 Department of Oral Anatomy, College of Dentistry, Gangneung Wonju National University, Gangneung 210-702, Republic of Korea.
  • 5 Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea. Electronic address: ik.kim@amc.seoul.kr.
  • 6 Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea; Department of Biological Chemistry, University of Science and Technology, Daejeun, Republic of Korea. Electronic address: jwlee5@kist.re.kr.
PMID: 26631318 DOI: 10.1016/j.bmcl.2015.11.043
Abstract

Gambogic acid (GA), a natural product with a xanthone structure, has a broad range of anti-proliferative effects on Cancer cell lines. We evaluated GA for its cytotoxic effects on T98G glioblastoma cells. GA exhibited potent anti-proliferative activity and induced Apoptosis in T98G glioblastoma cells in a dose-dependent manner. Incubation of cells with GA revealed apoptotic features including increased Bax and AIF expression, cytochrome c release, and cleavage of Caspase-3, -8, -9, and PARP, while Bcl-2 expression was downregulated. Furthermore, GA induced Reactive Oxygen Species (ROS) generation in T98G cells. Our results indicate that GA increases Bax- and AIF-associated apoptotic signaling in glioblastoma cells.

Keywords

Anticancer; Apoptosis; Gambogic acid; Glioblastoma; Reactive oxygen species (ROS).

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