2. Academic Validation
  3. Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

  • J Med Chem. 2016 Jun 23;59(12):5587-603. doi: 10.1021/acs.jmedchem.5b01485.
Elena Fernández-Álvaro 1,  W David Hong 2,  Gemma L Nixon 2,  Paul M O'Neill 2,  Félix Calderón 1
Affiliations

Affiliations

  • 1 Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline , c/Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
  • 2 Robert Robinson Laboratories, Department of Chemistry, University of Liverpool , Crown Street, Liverpool L69 7ZD, U.K.
PMID: 26791529 DOI: 10.1021/acs.jmedchem.5b01485
Abstract

Natural Products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these Natural Products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have reached the clinic.

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