Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Affiliations

• 1 Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, MA 02115;
• 2 The California Institute for Biomedical Research, La Jolla, CA 92037;
• 3 Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065;
• 4 Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129;
• 5 Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
• 6 Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, Vlaams Instituut voor Biotechnologie Leuven, 3000 Leuven, Belgium;
• 7 Department of Systems Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;
• 8 Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; Milstein Chemistry Core Facility, Weill Cornell Medical College, New York, NY 10065;
• 9 Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;
• 10 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.
• 11 The California Institute for Biomedical Research, La Jolla, CA 92037; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.
• 12 Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.