2. Academic Validation
  3. Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

  • Bioorg Med Chem Lett. 2016 Mar 1;26(5):1495-7. doi: 10.1016/j.bmcl.2015.09.010.
Cheng-jian Tan 1,  Yu Zhao 2,  Masuo Goto 2,  Kan-Yen Hsieh 3,  Xiao-ming Yang 2,  Susan L Morris-Natschke 2,  Li-na Liu 4,  Bao-yu Zhao 5,  Kuo-Hsiung Lee 6
Affiliations

Affiliations

  • 1 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; College of Chemistry and Environment, Guizhou Minzu University, Guiyang 550025, People's Republic of China. Electronic address: tcj1229@163.com.
  • 2 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
  • 3 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • 4 Department of Medical Biotechnology, Guiyang Medical University, Guiyang 550004, People's Republic of China.
  • 5 College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China. Electronic address: zhaobaoyu2005@163.com.
  • 6 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40447, Taiwan. Electronic address: khlee@unc.edu.
PMID: 26865176 DOI: 10.1016/j.bmcl.2015.09.010
Abstract

Ten Alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole Plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.

Keywords

Antiproliferative; Oxytropis ochrocephala; Poisonous plant; Sophoridine derivatives.

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