2. Academic Validation
  3. Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity

Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity

  • Bioorg Med Chem Lett. 2016 Apr 1;26(7):1760-1. doi: 10.1016/j.bmcl.2016.02.040.
Toshio Kaneda 1,  Haruka Yoshida 1,  Yuki Nakajima 1,  Minako Toishi 1,  Alfarius Eko Nugroho 1,  Hiroshi Morita 2
Affiliations

Affiliations

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
  • 2 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. Electronic address: moritah@hoshi.ac.jp.
PMID: 26923696 DOI: 10.1016/j.bmcl.2016.02.040
Abstract

Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic Peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity.

Keywords

Cyclic peptides; Cyclolinopeptides; Flaxseed; Linum usitatissimum; Osteoclast differentiation.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z