2. Academic Validation
  3. Eremophilane-Type Sesquiterpenoids from an Acremonium sp. Fungus Isolated from Deep-Sea Sediments

Eremophilane-Type Sesquiterpenoids from an Acremonium sp. Fungus Isolated from Deep-Sea Sediments

  • J Nat Prod. 2016 Apr 22;79(4):1035-47. doi: 10.1021/acs.jnatprod.5b01103.
Zhongbin Cheng 1,  Jingjun Zhao 2,  Dong Liu 1,  Peter Proksch 3,  Zhimin Zhao 2,  Wenhan Lin 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural and Biomimetic Drugs, Institute of Ocean Research, Peking University , Beijing, 100191, People's Republic of China.
  • 2 School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, Guangdong 510006, People's Republic of China.
  • 3 Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf, Germany.
PMID: 26928174 DOI: 10.1021/acs.jnatprod.5b01103
Abstract

Chemical examination of an EtOAc extract of a cultured Acremonium sp. fungus from deep-sea sediments resulted in the isolation of 15 new eremophilane-type sesquiterpenoids, namely, acremeremophilanes A-O (1-15), together with seven known analogues. The structures of new compounds were determined through extensive spectroscopic analyses, in association with chemical conversions and ECD calculations for configurational assignments. The PKS-derived 4-hexenoic acid unit in 2-6 is rarely found in nature. All compounds were evaluated for inhibitory effects toward nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compounds 2-6 and 14 exhibited inhibitory effects with IC50 values ranging from 8 to 45 μM.

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