Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review

Steroid Sulfatase (STS) plays a momentous role in the conversion of sulfated Steroids, which are biologically inactive, into biologically active un-sulfated steroid Hormones, which support the development and growth of a number of hormone-dependent cancers, including breast Cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and Other steroid-dependent cancers. The present review concentrates on broad chemical classification of Steroid Sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of Cancer, estradiol precursors, STS Enzyme and its role in breast Cancer is herein described.

Breast cancer; Non-steroidal non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Steroid sulfamate based inhibitors; Sulfatase inhibitor's chemistry.