Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging

The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal Cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.

astemizole; cell imaging; fluorescent probes; hERG potassium channel.