2. Academic Validation
  3. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity

Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2755-2759. doi: 10.1016/j.bmcl.2016.04.077.
Mayuramas Sang-Ngern 1,  Ui Joung Youn 1,  Eun-Jung Park 1,  Tamara P Kondratyuk 1,  Charles J Simmons 2,  Marisa M Wall 3,  Michael Ruf 4,  Sam E Lorch 5,  Ethyn Leong 6,  John M Pezzuto 1,  Leng Chee Chang 7
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States.
  • 2 Chemistry Department, University of Hawai'i at Hilo, Hilo, HI 96720, United States.
  • 3 United States Department of Agriculture, Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, Hilo, HI 96720, United States.
  • 4 Bruker AXS Inc., East Cheryl Parkway, Madison, WI 53711, United States.
  • 5 Lani ko Honua Berry Farm, Pepeekeo, HI 96783, United States.
  • 6 Department of Food Science, Cornell University College of Agriculture and Life Science, Founders Hall, Ithaca, NY 14853, United States.
  • 7 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States. Electronic address: lengchee@hawaii.edu.
PMID: 27210437 DOI: 10.1016/j.bmcl.2016.04.077
Abstract

Three new withanolides, physaperuvin G (1), with physaperuvins I (2), and J (3), along with seven known derivatives (4-10), were isolated from the aerial parts of Physalis peruviana. The structures of 1-3 were determined by NMR, X-ray diffraction, and mass spectrometry. Compounds 1-10 were evaluated in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells. Compounds 4, 5, and 10 with potent nitric oxide inhibitory activity in LPS-activated RAW 264.7 cells, with IC50 values in the range of 0.32-7.8μM. In addition, all compounds were evaluated for potential to inhibit tumor necrosis factor-alpha (TNF-α)-activated nuclear factor-kappa B (NF-κB) activity with transfected human embryonic kidney cells 293. Compounds 4-7 inhibited TNF-α-induced NF-κB activity with IC50 values in the range of 0.04-5.6μM.

Keywords

Anti-inflammatory activity; Physalis peruviana; Withanolides; X-ray crystallography.

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