5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Affiliations

• 1 Departments of Chemistry and Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA.
• 2 Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, CP205/1, Boulevard du Triomphe, Brussels, Belgium.
• 3 Service de Neurochirurgie, Hôpital Erasme, ULB, 808 route de Lennik, 1070 Brussels, Belgium.
• 4 Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
• 5 Dipartimento di Scienze Chimiche, Universita' di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126 Napoli, Italy.
• 6 Greehey Children's Cancer Research Institute, UT Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, USA.
• 7 Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
• 8 Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
• 9 Department of Chemistry, North Caucasus University, 1a Pushkin St., Stavropol 355009, Russian Federation.
• 10 Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. Electronic address: a_k76@txstate.edu.
• 11 Departments of Chemistry and Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. Electronic address: lfrolova@nmt.edu.