2. Academic Validation
  3. Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

  • Bioorg Med Chem Lett. 2016 Aug 15;26(16):3955-7. doi: 10.1016/j.bmcl.2016.07.007.
Germán F Giri 1,  Mauro Danielli 2,  Raúl A Marinelli 2,  Rolando A Spanevello 1
Affiliations

Affiliations

  • 1 Instituto de Química de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
  • 2 Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
PMID: 27422336 DOI: 10.1016/j.bmcl.2016.07.007
Abstract

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.

Keywords

Cancer cell lines; Cytotoxic activity; Hepatocarcinoma; Levoglucosenone; Michael addition.

Figures
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z