2. Academic Validation
  3. Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity

Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity

  • Bioorg Med Chem Lett. 2016 Oct 1;26(19):4832-4836. doi: 10.1016/j.bmcl.2016.08.019.
Hua Jiang 1,  Shuang-Gang Ma 1,  Yong Li 1,  Yun-Bao Liu 1,  Li Li 1,  Jing Qu 1,  Shi-Shan Yu 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address: yushishan@imm.ac.cn.
PMID: 27592135 DOI: 10.1016/j.bmcl.2016.08.019
Abstract

Three new spirobisnaphthalenes (1-3), a new, natural spirobisnaphthalene product (4), and two new 12-membered ring lactones (11-12), with six known compounds (5-10), were isolated from the seeds of Strychnos angustiflora. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-4 were assigned by computational methods. Compounds 1, 5 and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 4.85, 2.05, and 1.16μM, respectively (positive control curcumin, IC50=1.42μM). This is the first report on the anti-inflammatory activities of spirobisnaphthalenes.

Keywords

Anti-inflammatory activity; Lactone; Spirobisnaphthalene; Strychnaceae; Strychnos angustiflora.

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