2. Academic Validation
  3. Structural Characterization and Assessment of the Cytotoxicity of 2,3-Dihydro-1H-indene Derivatives and Coumarin Glucosides from the Bark of Streblus indicus

Structural Characterization and Assessment of the Cytotoxicity of 2,3-Dihydro-1H-indene Derivatives and Coumarin Glucosides from the Bark of Streblus indicus

  • J Nat Prod. 2016 Oct 28;79(10):2472-2478. doi: 10.1021/acs.jnatprod.6b00306.
Ruijie He 1 2,  Xishan Huang 3,  Yanjun Zhang 1,  Liangdeng Wu 1,  Hui Nie 1,  Dexiong Zhou 1,  Buming Liu 4,  Shengping Deng 1,  Ruiyun Yang 1,  Shuai Huang 1,  Zhijie Nong 1,  Jun Li 1,  Yan Huang 4
Affiliations

Affiliations

  • 1 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University , Guilin 541004, People's Republic of China.
  • 2 Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany , Guilin 541006, People's Republic of China.
  • 3 School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275, People's Republic of China.
  • 4 Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards , Nanning 530022, People's Republic of China.
PMID: 27704822 DOI: 10.1021/acs.jnatprod.6b00306
Abstract

A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4-7); and four known coumarin glucosides (8-11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1-11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50 values in the range of 2.2 ± 0.1 to 7.2 ± 0.9 μM.

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