2. Academic Validation
  3. Acetophenone Monomers from Acronychia trifoliolata

Acetophenone Monomers from Acronychia trifoliolata

  • J Nat Prod. 2016 Nov 23;79(11):2883-2889. doi: 10.1021/acs.jnatprod.6b00645.
Katsunori Miyake 1,  Airi Suzuki 1,  Chihiro Morita 1,  Masuo Goto 2,  David J Newman 3,  Barry R O'Keefe 4,  Susan L Morris-Natschke 2,  Kuo-Hsiung Lee 2 5,  Kyoko Nakagawa-Goto 1 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa, 920-1192, Japan.
  • 2 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-7568, United States.
  • 3 NIH Special Volunteer, Wayne, Pennsylvania 19087, United States.
  • 4 Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI at Frederick , Frederick, Maryland 21702-1201, United States.
  • 5 Chinese Medicine Research and Development Center, China Medical University and Hospital , 2 Yuh-Der Road, Taichung, 40447, Taiwan.
PMID: 27797192 DOI: 10.1021/acs.jnatprod.6b00645
Abstract

Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH3OH/CH2Cl2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human Cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity.

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