2. Academic Validation
  3. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

  • Molecules. 2016 Nov 23;21(11):1600. doi: 10.3390/molecules21111600.
Kuo Gao 1,  Chenglong Zheng 2 3,  Tong Wang 4,  Huihui Zhao 5,  Juan Wang 6,  Zhiyong Wang 7,  Xing Zhai 8,  Zijun Jia 9,  Jianxin Chen 10,  Yingwu Zhou 11,  Wei Wang 12
Affiliations

Affiliations

  • 1 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. linfengtingchan@foxmail.com.
  • 2 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. zheng1633@163.com.
  • 3 Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. zheng1633@163.com.
  • 4 Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. selenss@163.com.
  • 5 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. hh686@126.com.
  • 6 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. doctorjuanwang@163.com.
  • 7 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. bucmwzy@126.com.
  • 8 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. zhaixing_918@163.com.
  • 9 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. 15652605582@163.com.
  • 10 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. cjx@bucm.edu.cn.
  • 11 Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. 15001394600@163.com.
  • 12 Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. wangwei@bucm.edu.cn.
PMID: 27886092 DOI: 10.3390/molecules21111600
Abstract

1-Deoxynojirimycin (DNJ, C₆H13NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and Commelina communis (dayflower) as well as from several Bacterial strains such as Bacillus and Streptomyces species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and Antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.

Keywords

Bacillus; anti-obesity; antihyperglycemic; antiviral; fermentation; iminosugar; molecular targets; mulberry; silkworms.

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