2. Academic Validation
  3. Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂

  • Mar Drugs. 2016 Nov 25;14(12):217. doi: 10.3390/md14120217.
Hongju Liu 1 2,  Senhua Chen 3,  Weiyang Liu 4,  Yayue Liu 5,  Xishan Huang 6,  Zhigang She 7 8
Affiliations

Affiliations

  • 1 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuhj8@mail2.sysu.edu.cn.
  • 2 School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuhj8@mail2.sysu.edu.cn.
  • 3 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. chensh65@mail2.sysu.edu.cn.
  • 4 School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuwy79@yahoo.com.
  • 5 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuyayue@mail2.sysu.edu.cn.
  • 6 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. huangxishan13@foxmail.com.
  • 7 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.
  • 8 South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. cesshzhg@mail.sysu.edu.cn.
PMID: 27897975 DOI: 10.3390/md14120217
Abstract

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known Xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 μg/mL.

Keywords

Penicillium sp.; immunosuppressive activity; marine fungus; polyketides.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z