2. Academic Validation
  3. Polycycloiridals with a Cyclopentane Ring from Iris tectorum

Polycycloiridals with a Cyclopentane Ring from Iris tectorum

  • J Nat Prod. 2017 Jan 27;80(1):156-161. doi: 10.1021/acs.jnatprod.6b00796.
Chun-Lei Zhang 1 2,  Zhi-You Hao 1,  Yan-Fei Liu 1,  Yan Wang 1,  Guo-Ru Shi 1,  Zhi-Bo Jiang 1,  Ruo-Yun Chen 1,  Zheng-Yu Cao 2,  De-Quan Yu 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
  • 2 Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University , Nanjing 211198, People's Republic of China.
PMID: 28032759 DOI: 10.1021/acs.jnatprod.6b00796
Abstract

Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E-J (1-6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC50 value of 0.54 μM.

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