2. Academic Validation
  3. Anticancer agents interacting with membrane glucose transporters

Anticancer agents interacting with membrane glucose transporters

  • Medchemcomm. 2016 Sep 1;7(9):1716-1729. doi: 10.1039/C6MD00287K.
C Granchi 1,  S Fortunato 1,  F Minutolo 1
Affiliations

Affiliation

  • 1 Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
PMID: 28042452 DOI: 10.1039/C6MD00287K
Abstract

The altered metabolism observed in Cancer cells generally consists in increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of Cancer cells. Therefore GLUTs are considered as suitable targets for the treatment of Cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective Anticancer agents.

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