The influence of 2-acetoxy-1, 3-di(nitroimidazolyl)propane derivatives on human red blood cell membrane ATP-ase activity

The effect of two nitroimidazoles, 2-acetoxyl-1,3-bis-(2'-methyl-4'-nitro-1'-imidazolyl)propane (Rs-029) and 2-acetoxy-1-(2'-methyl-4'-nitro-1'-imidazolyl)-3-(2''-methyl-5''-nitro- 1- nitroimidazolyl)propane (Rs-034) on ATP level and erythrocyte membrane ATP-ase activity was studied. The action of these compounds on erythrocyte membrane ATP-ase activity differed depending on the structure of nitroimidazoles. Only Rs-029 significantly inhibited (Na+K+) ATP-ase activity and activated Mg2+ ATP-ase. Both, Rs-029 and Rs-034 decreased ATP content in red blood cells after three hours incubation in the presence of plasma.