2. Academic Validation
  3. α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana

α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana

  • J Nat Prod. 2017 Apr 28;80(4):1087-1095. doi: 10.1021/acs.jnatprod.7b00006.
Phu Hoang Dang 1,  Hai Xuan Nguyen 1,  Truc Thanh Thi Duong 1,  Thao Kim Thi Tran 1,  Phuc Thi Nguyen 1,  Trang Kieu Thi Vu 1,  Hung Chi Vuong 2,  Nguyen Huu Trong Phan 1,  Mai Thanh Thi Nguyen 1 3,  Nhan Trung Nguyen 1 3,  Suresh Awale 4
Affiliations

Affiliations

  • 1 Faculty of Chemistry, VNUHCM-University of Science , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
  • 2 Tay Nguyen Herbals JSC , Tu Tra Ward, Don Duong District, Lam Dong Province Vietnam.
  • 3 Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
  • 4 Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
PMID: 28240909 DOI: 10.1021/acs.jnatprod.7b00006
Abstract

From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical Cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.

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