2. Academic Validation
  3. Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

  • J Nat Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151.
Airi Suzuki 1,  Yohei Saito 1,  Shuichi Fukuyoshi 1,  Masuo Goto 2,  Katsunori Miyake 3,  David J Newman 4,  Barry R O'Keefe,  Kuo-Hsiung Lee 2 5,  Kyoko Nakagawa-Goto 1 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa 920-1192, Japan.
  • 2 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-7568, United States.
  • 3 Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
  • 4 NIH Special Volunteer , Wayne, Pennsylvania 19087, United States.
  • 5 Chinese Medicine Research and Development Center, China Medical University and Hospital , 2 Yuh-Der Road, Taichung, 40447, Taiwan.
PMID: 28290698 DOI: 10.1021/acs.jnatprod.6b01151
Abstract

A bioactive CH3OH-CH2Cl2 (1:1) extract of the bark of Laetia corymbulosa provided five new clerodane diterpenes with an isozuelanin skeleton, designated as corymbulosins D-H (1-5), as well as the known corymbulosins B (6) and C (7), for which the relative configurations were not previously determined. The structures of 1-5 were characterized on the basis of 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of all isolated compounds 1-7 were verified through chemical methods, including modified Mosher esterifications or oxidation of the hydroxy group at C-2, ECD experiments, and spectroscopic data comparison. The isolated compounds were evaluated for antiproliferative activity against a small panel of human Cancer cell lines.

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