2. Academic Validation
  3. Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice

Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice

  • J Ethnopharmacol. 2017 May 5:203:279-287. doi: 10.1016/j.jep.2017.03.055.
Jun Yeon Park 1,  Yun Kyung Lee 2,  Dong-Soo Lee 3,  Jeong-Eun Yoo 4,  Myoung-Sook Shin 5,  Noriko Yamabe 6,  Su-Nam Kim 7,  Seulah Lee 8,  Ki Hyun Kim 9,  Hae-Jeung Lee 10,  Seok Sun Roh 11,  Ki Sung Kang 12
Affiliations

Affiliations

  • 1 College of Korean Medicine, Gachon University, Seongnam 461-701, South Korea. Electronic address: rhemf@hanmail.net.
  • 2 Department of Korean Medicine, College of Korean Medicine, Daejeon University, Daejeon 300-716, South Korea. Electronic address: octantis@hanmail.net.
  • 3 Institute of Human-Environment Interface Biology, Biomedical Research Institute, Department of Dermatology, Seoul National University College of Medicine, Seoul 110-744, South Korea. Electronic address: johnny.dslee@snu.ac.kr.
  • 4 Department of Gynecology, School of Korean Medicine, Daejeon University, Daejeon 302-869, South Korea. Electronic address: koreadryoo@gmail.com.
  • 5 Natural Constituents Research Center, Korea Institute of Science and Technology, Gangneung 210-340, South Korea. Electronic address: ms.shin@kist.re.kr.
  • 6 College of Korean Medicine, Gachon University, Seongnam 461-701, South Korea. Electronic address: norikoy@gachon.ac.kr.
  • 7 Natural Constituents Research Center, Korea Institute of Science and Technology, Gangneung 210-340, South Korea. Electronic address: snkim@kist.re.kr.
  • 8 School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea. Electronic address: sarahlee0801@gmail.com.
  • 9 School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea. Electronic address: khkim83@skku.edu.
  • 10 Department of Food and Nutrition, Gachon University, Seongnam-si, Gyeonggi-do, South Korea. Electronic address: skysea@gachon.ac.kr.
  • 11 Department of Korean Medicine, College of Korean Medicine, Daejeon University, Daejeon 300-716, South Korea. Electronic address: rssdr@hanmail.net.
  • 12 College of Korean Medicine, Gachon University, Seongnam 461-701, South Korea. Electronic address: kkang@gachon.ac.kr.
PMID: 28389357 DOI: 10.1016/j.jep.2017.03.055
Abstract

Ethnopharmacological relevance: Resin known as Resina Pini is listed in the Korean and Japanese pharmacopoeias and has been used for treating skin wounds and inflammation. Resin is composed of more than 50% abietic acid and 10% neutral substances.

Objective: In the present study, the wound-healing effects of abietic acid and the possible underlying mechanism of action were investigated in various in vitro and in vivo models.

Materials and methods: The effects of abietic acid on tube formation and migration were measured in human umbilical vein vascular endothelial cells (HUVECs). Protein expression of mitogen-activated protein kinase (MAPK) activation was evaluated via Western blotting analysis. The wound-healing effects of abietic acid were assessed using a mouse model of cutaneous wounds.

Results: The results showed that abietic acid enhanced cell migration and tube formation in HUVECs. Abietic acid induced significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Additionally, 0.8μM abietic acid-treated groups showed accelerated wound closure compared to the controls in a mouse model of cutaneous wounds.

Conclusion: The current data indicate that abietic acid treatment elevated cell migration and tube formation in HUVECs by the activation of ERK and p38 MAPKs. We suggest that abietic acid can be developed as a wound-healing agent.

Keywords

Abietic acid; MAPKs; Resin; Resina Pini; Tube formation; Wound healing.

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