2. Academic Validation
  3. Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101

Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101

  • J Nat Prod. 2017 May 26;80(5):1668-1673. doi: 10.1021/acs.jnatprod.7b00269.
Minghe Luo 1 2,  Zhaomeng Cui 3,  Hongbo Huang 1,  Xianqin Song 2,  Aijun Sun 1,  Yongjun Dang 3,  Laichun Lu 2,  Jianhua Ju 1 4
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 Xingang Road West, Guangzhou 510301, People's Republic of China.
  • 2 Department of Pharmacy, Institute of Surgery Research, Daping Hospital, and College of Pharmacy, Third Military Medical University , 10 Changjiang Branch Road, Chongqing 400042, People's Republic of China.
  • 3 Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College , 130 Dong An Road, Shanghai 200032, People's Republic of China.
  • 4 University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 10049, People's Republic of China.
PMID: 28509552 DOI: 10.1021/acs.jnatprod.7b00269
Abstract

Emodacidamides A-H (1-8), Natural Products featuring anthraquinone-amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known Anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities. Emodacidamides A (1), C (3), D (4), and E (5) inhibited interleukin-2 secretion from Jurkat cells with IC50 values of 4.1, 5.1, 12, and 5.4 μM, respectively.

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