2. Academic Validation
  3. Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb

Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb

  • J Microbiol Biotechnol. 2017 Jul 28;27(7):1272-1275. doi: 10.4014/jmb.1612.12051.
Tae Hoon Kang 1,  Yun Mi Lee 1,  Won Jung Lee 1,  Eui Il Hwang 2,  Ki Duk Park 3,  Gyang Ja Choi 4,  Jae Sun Moon 1,  Ho-Yong Park 1,  Sung Uk Kim 1
Affiliations

Affiliations

  • 1 Industrial Bio-materials Research Center, KRIBB, Daejeon 34141, Republic of Korea.
  • 2 Technical Research Center, KT&G R&D Headquaters, Daejeon 34128, Republic of Korea.
  • 3 Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul 02792, Republic of Korea.
  • 4 Center for Eco-friendly New Materials, KRICT, Daejeon 34114, Republic of Korea.
PMID: 28535608 DOI: 10.4014/jmb.1612.12051
Abstract

Two dimeric Sesquiterpenes were separated from Chloranthus japonicus Sieb. and identified as shizukaols C and F. They exhibited potent Antifungal activities (MICs = 4-16 μg/ml) in vitro against various plant pathogenic fungi (Pythium ultimum, Phytophthora infestans, Botrytis cinerea, Colletotrichum lagenarium, Alternaria kikuchiana, and Magnaporthe grisea). Shizukaol C showed 88% and 91% protective activities in the greenhouse against Puccinia recondita (wheat leaf rust) and Phytophthora infestans (tomato late blight), respectively, at 100 μg/ml; shizukaol F exhibited 93% Antifungal activity against Puccinia recondita at the same concentration. Therefore, these compounds might serve as interesting candidates for effective Antifungal agents.

Keywords

Chloranthus japonicus Sieb.; Phytophthora infestans; Puccinia recondite; antifungal activity; shizukaol C; shizukaol F.

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