2. Academic Validation
  3. CAR: A key regulator of adhesion and inflammation

CAR: A key regulator of adhesion and inflammation

  • Int J Biochem Cell Biol. 2017 Aug;89:1-5. doi: 10.1016/j.biocel.2017.05.025.
Elena Ortiz-Zapater 1,  George Santis 2,  Maddy Parsons 3
Affiliations

Affiliations

  • 1 Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guys Campus, London, SE1 1UL, UK; Division of Asthma, Allergy & Lung Biology, King's College London, 5th Floor Tower Wing, Guy's Hospital Campus, London, SE1 1UL, UK.
  • 2 Division of Asthma, Allergy & Lung Biology, King's College London, 5th Floor Tower Wing, Guy's Hospital Campus, London, SE1 1UL, UK.
  • 3 Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guys Campus, London, SE1 1UL, UK. Electronic address: maddy.parsons@kcl.ac.uk.
PMID: 28545889 DOI: 10.1016/j.biocel.2017.05.025
Abstract

The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell-cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as Cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.

Keywords

Cancer; Cell-cell adhesion; Coxsackievirus adenovirus receptor; Inflammation; Transmigration.

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