Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates Cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast Cancer, colon Cancer, lung Cancer, gastric Cancer, oesophageal Cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and Cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of Cancer proliferation. Knowledge about nuclear localization and nuclear level expression of YB-1 in different cancers has been correlated with prospective prognosis of Cancer. This review discusses the prospects of YB-1 as a potential biomarker as well as therapeutic target in lieu of their role during Cancer progression and multidrug resistance.

Y Box Protein-1; biomarker; cancer.