2. Academic Validation
  3. Sesquiterpenes from the Endophyte Glomerella cingulata

Sesquiterpenes from the Endophyte Glomerella cingulata

  • J Nat Prod. 2017 Oct 27;80(10):2609-2614. doi: 10.1021/acs.jnatprod.7b00054.
Yunbao Liu 1,  Yong Li 1,  Zhen Liu 1,  Li Li 1,  Jing Qu 1,  Shuanggang Ma 1,  Ridao Chen 1,  Jungui Dai 1,  Shishan Yu 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
PMID: 29035525 DOI: 10.1021/acs.jnatprod.7b00054
Abstract

From the cultured endophytic fungus Glomerella cingulata isolated from a toxic plant, Gelsemium elegans, one new phenanthrene (1), four new Sesquiterpenes (2-5), and three known Sesquiterpenes (6-8) were isolated. Their structures were elucidated using spectroscopic methods. Based on the ECD calculations, the absolute configurations of the new compounds were determined. Compounds 2, 4, and 5 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells by 50.6, 36.1, and 29.4%, respectively, at 1 μM (positive control curcumin, IC50 = 4.0 μM).

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