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  3. In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles

In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles

  • Molecules. 2017 Dec 12;22(12):2208. doi: 10.3390/molecules22122208.
Yonghua Zhan 1 2,  Wenhua Zhan 3 4,  Hanrui Li 5,  Xinyi Xu 6,  Xu Cao 7,  Shouping Zhu 8,  Jimin Liang 9,  Xueli Chen 10
Affiliations

Affiliations

  • 1 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. yhzhan@xidian.edu.cn.
  • 2 Xidian-Ningbo Information Technology Institute, Xidian University, Xi'an 710071, Shaanxi, China. yhzhan@xidian.edu.cn.
  • 3 Department of Radiotherapy, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China. zhanwhgood@163.com.
  • 4 Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China. zhanwhgood@163.com.
  • 5 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. hrli330@163.com.
  • 6 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. xyxu@xidian.edu.cn.
  • 7 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. caoxu327@gmail.com.
  • 8 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. spzhu@xidian.edu.cn.
  • 9 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. jimleung@mail.xidian.edu.cn.
  • 10 Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China. xlchen@xidian.edu.cn.
PMID: 29231865 DOI: 10.3390/molecules22122208
Abstract

Multifunctional manganese oxide nanoparticles (NPs) with impressive enhanced T₁ contrast ability show great promise in biomedical diagnosis. Herein, we developed a dual-modality imaging agent system based on polyethylene glycol (PEG)-coated manganese oxide NPs conjugated with organic dye (Cy7.5), which functions as a fluorescence imaging (FI) agent as well as a magnetic resonance imaging (MRI) imaging agent. The formed Mn₃O₄@PEG-Cy7.5 NPs with the size of ~10 nm exhibit good colloidal stability in different physiological media. Serial FI and MRI studies that non-invasively assessed the bio-distribution pattern and the feasibility for in vivo dual-modality imaging-guided lymph node mapping have been investigated. In addition, histological and biochemical analyses exhibited low toxicity even at a dose of 20 mg/kg in vivo. Since Mn₃O₄@PEG-Cy7.5 NPs exhibited desirable properties as imaging agents and good biocompatibility, this work offers a robust, safe, and accurate diagnostic platform based on manganese oxide NPs for tumor metastasis diagnosis.

Keywords

dual-modality; fluorescence imaging; lymph node; magnetic resonance imaging; manganese oxide nanoparticles.

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