2. Academic Validation
  3. Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum

Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum

  • Bioorg Med Chem Lett. 2018 Feb 1;28(3):355-359. doi: 10.1016/j.bmcl.2017.12.039.
Jinlian Zhao 1,  Jiamin Feng 1,  Zhen Tan 1,  Jimei Liu 1,  Min Zhang 1,  Ridao Chen 1,  Kebo Xie 1,  Dawei Chen 1,  Yan Li 1,  Xiaoguang Chen 1,  Jungui Dai 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: jgdai@imm.ac.cn.
PMID: 29279273 DOI: 10.1016/j.bmcl.2017.12.039
Abstract

Bistachybotrysins A-C (1-3), three phenylspirodrimane dimers representing an unusual [6,6,7,6]-tetracyclic skeleton with a central 2,10-dioxabicyclo[4.3.1]decan-7-ol core fused with two phenyl units, were isolated from a Fungal strain, Stachybotrys chartarum CGMCC 3.5365. The structures of 1-3 were elucidated through extensive spectroscopic data analysis, including Mo2(AcO)4-induced and calculated electronic circular dichroism (ECD). 1 and 2 exhibited potent cytotoxicity against four human tumor cell lines with IC50 values in the range of 2.8-7.5 μM. Furthermore, a possible biogenesis for 1-3 is proposed.

Keywords

Bistachybotrysins; Cytotoxicity; Meroterpenoid; Phenylspirodrimane dimer; Stachybotrys chartarum.

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