2. Academic Validation
  3. Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum

Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum

  • J Nat Prod. 2018 Feb 23;81(2):219-226. doi: 10.1021/acs.jnatprod.6b00873.
Varun Pratap Singh 1 2,  Nalli Yedukondalu 3 4,  Vandana Sharma 5,  Manoj Kushwaha 5,  Richa Sharma 3 6,  Asha Chaubey 3 6,  Anil Kumar 2,  Deepika Singh 1 3 5,  Ram A Vishwakarma 1 3
Affiliations

Affiliations

  • 1 Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.
  • 2 Department of Biotechnology, Faculty of Sciences, Shri Mata Vaishno Devi University , Katra, Jammu and Kashmir 182320, India.
  • 3 Academy of Scientific and Innovative Research , Jammu 180 001, India.
  • 4 Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.
  • 5 Quality Control and Quality Assurance, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.
  • 6 Fermentation Technology Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.
PMID: 29373791 DOI: 10.1021/acs.jnatprod.6b00873
Abstract

Four novel lipovelutibols A (1), B (2), C (3), and D (4) containing six amino acid residues with leucinol at the C-terminus and a fatty acyl moiety (n-octanoyl) at its N-terminus were isolated from the psychrotrophic fungus Trichoderma velutinum collected from the Himalayan cold habitat. The structures (1-4) were determined by NMR and MS/MS, and the stereochemistry of Amino acids by Marfey's method. Lipopeptaibols 2 and 4 were found to contain d-isovaline, a nonproteinogenic amino acid, but lacked α-aminoisobutyric acid, characteristic of peptaibols. Cytotoxic activity of 2 and 4 was observed against HL-60, LS180, MDA-MB-231, and A549 Cancer cell lines.

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