2. Academic Validation
  3. Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii

Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii

  • J Nat Prod. 2018 Feb 23;81(2):418-422. doi: 10.1021/acs.jnatprod.7b00909.
Lei-Yu Ke 1 2 3,  Yu Zhang 1,  Meng-Yuan Xia 1 2,  Jing-Xian Zhuo 1,  Yue-Hu Wang 1 2,  Chun-Lin Long 4
Affiliations

Affiliations

  • 1 Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
  • 2 Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences , Yezin, Nay Pyi Taw 05282, Myanmar.
  • 3 University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
  • 4 College of Life and Environmental Sciences, Minzu University of China , Beijing 100081, People's Republic of China.
PMID: 29412669 DOI: 10.1021/acs.jnatprod.7b00909
Abstract

A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4→3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane Diterpenoids through a Diels-Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1-3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, Diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three Diterpenoids (1-3) were evaluated for their growth-inhibitory activities against several human Cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 μM).

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