2. Academic Validation
  3. Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity

Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity

  • J Nat Prod. 2018 Apr 27;81(4):791-797. doi: 10.1021/acs.jnatprod.7b00850.
Jian-Jun Chen 1,  Mostafa E Rateb 1,  Melissa S Love 2,  Zhengren Xu 1,  Dong Yang 1 3,  Xiangcheng Zhu 4 5,  Yong Huang 4,  Li-Xing Zhao 6,  Yi Jiang 6,  Yanwen Duan 4 5,  Case W McNamara 2,  Ben Shen 1 3 7
Affiliations

Affiliations

  • 1 Department of Chemistry , The Scripps Research Institute , Jupiter , Florida 33458 , United States.
  • 2 California Institute for Biomedical Research , La Jolla , California 92037 , United States.
  • 3 Natural Products Library Initiative at The Scripps Research Institute , The Scripps Research Institute , Jupiter , Florida 33458 , United States.
  • 4 Xiangya International Academy of Translational Medicine , Central South University , Changsha , Hunan 410013 , People's Republic of China.
  • 5 Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery , Changsha , Hunan 410013 , People's Republic of China.
  • 6 Yunnan Institute of Microbiology , Yunnan University , Kunming , Yunnan 650091 , People's Republic of China.
  • 7 Department of Molecular Medicine , The Scripps Research Institute , Jupiter , Florida 33458 , United States.
PMID: 29469575 DOI: 10.1021/acs.jnatprod.7b00850
Abstract

A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti- Cryptosporidium drug development.

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