2. Academic Validation
  3. Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats

Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats

  • Biomed Pharmacother. 2018 May;101:608-616. doi: 10.1016/j.biopha.2018.02.131.
Chang Liu 1,  Yan-Jun Shen 2,  Qing-Bo Tu 3,  Yan-Ran Zhao 3,  Hao Guo 4,  Juan Wang 5,  Li Zhang 6,  Hua-Wei Shi 2,  Yun Sun 7
Affiliations

Affiliations

  • 1 College of Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, PR China; School of Pharmacy, University of Rhode Island, RI, 02881, United States.
  • 2 College of Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, PR China.
  • 3 College of Hanlin, Nanjing University of China Medicine, Taizhou 225300, Jiangsu, PR China.
  • 4 School of Pharmacy, University of Rhode Island, RI, 02881, United States; Department of Dermatology, No. 1 Hospital of China Medical University, 155N. Nanjing Street, Shenyang 110001, PR China.
  • 5 College of Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, PR China; College of Hanlin, Nanjing University of China Medicine, Taizhou 225300, Jiangsu, PR China.
  • 6 School of Pharmacy, University of Missouri-Kansas City, MO, 64108, United States.
  • 7 College of Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, PR China; College of Hanlin, Nanjing University of China Medicine, Taizhou 225300, Jiangsu, PR China. Electronic address: ysun@yzu.edu.cn.
PMID: 29518607 DOI: 10.1016/j.biopha.2018.02.131
Abstract

Pedunculoside (PE) is a novel triterpene saponin extracted from the dried barks of Ilex rotunda Thunb. The present study aims to explore lipid-lowering effects of PE on hyperlipidemia rat induced by high-fat diet. The rats were fed with the high-fat diet and subjected to intragastric administration of PE at doses of 30, 15, or 5 mg/kg daily for 7 weeks. The results demonstrated that treatment with PE for 7-week dramatically decreased serum total Cholesterol (TC) and low-density lipoprotein Cholesterol (LDL-C) and reduced liver TC in hyperlipidemia rat induced by high-fat diet. Furthermore, the results also showed that PE modulated the expression of Enzymes involved in lipid metabolism including Peroxisome Proliferator-activated Receptor α (PPAR-α), sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FAS) and stearoyl CoA desaturase-1 (SCD-1) mRNA in liver. Besides, PE-treated group decreased weights and diameters of epididymal adipose hyperlipidemia rat. Mechanism study demonstrated that PE regulated PPAR-γ, CCAAT/Enhancer-binding Protein α (C/EBPα)、and SREBP-1 expression as well as inhibited phosphorylation of AMPK in MDI (methylisobutylxanthine, dexamethasone, Insulin) induced-3T3L1 cells. Molecular Docking confirmed interaction between PE with proteins involving PPAR-γ, C/EBPα and SREBP-1. In summary, these findings may support that PE is a novel lipid-lowering drug candidate.

Keywords

FAS; Hyperlipidemia; PPAR-α; SCD-1; SREBP-1c; Triterpene saponin.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z