2. Academic Validation
  3. Current advance in biological production of malic acid using wild type and metabolic engineered strains

Current advance in biological production of malic acid using wild type and metabolic engineered strains

  • Bioresour Technol. 2018 Jun;258:345-353. doi: 10.1016/j.biortech.2018.03.001.
Zhongxue Dai 1,  Huiyuan Zhou 1,  Shangjie Zhang 1,  Honglian Gu 1,  Qiao Yang 1,  Wenming Zhang 2,  Weiliang Dong 2,  Jiangfeng Ma 2,  Yan Fang 2,  Min Jiang 3,  Fengxue Xin 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China.
  • 2 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211800, PR China.
  • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211800, PR China. Electronic address: bioengine@njtech.edu.cn.
PMID: 29550171 DOI: 10.1016/j.biortech.2018.03.001
Abstract

Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches.

Keywords

Biosynthesis; Carbon dioxide; Metabolic engineering; Renewable resources; l-Malic acid.

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