2. Academic Validation
  3. Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora

Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora

  • Bioorg Med Chem Lett. 2018 Jun 1;28(10):1860-1863. doi: 10.1016/j.bmcl.2018.04.006.
Lin-Yang Cheng 1,  Chun-Lin Chen 2,  Yueh-Hsiung Kuo 3,  Tsung-Hsien Chang 4,  I-Wei Lin 5,  Shih-Wei Wang 5,  Mei-Ing Chung 1,  Jih-Jung Chen 6
Affiliations

Affiliations

  • 1 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • 2 Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
  • 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan.
  • 4 Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
  • 5 Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
  • 6 Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: chenjj@ym.edu.tw.
PMID: 29655982 DOI: 10.1016/j.bmcl.2018.04.006
Abstract

A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Garcinia multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1-3 were evaluated in human endothelial progenitor cells (EPCs) and Cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate Cancer cell line PC-3 with GI50 values of 4.3 ± 1.6 and 6.6 ± 0.4 μM, respectively.

Keywords

Angiogenesis inhibitor; Garcimultiflorone K; Garcinia multiflora; Guttiferae; Polyprenylated polycyclic acylphloroglucinol.

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