2. Academic Validation
  3. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

  • Nat Commun. 2018 Apr 23;9(1):1606. doi: 10.1038/s41467-018-04075-1.
Wooseong Lee 1,  Seung-Hoon Lee 1,  Minwoo Kim 1,  Jae-Su Moon 1,  Geon-Woo Kim 1,  Hae-Gwang Jung 1,  In Hwang Kim 2,  Ji Eun Oh 3,  Hi Eun Jung 4,  Heung Kyu Lee 3 4,  Keun Bon Ku 5,  Dae-Gyun Ahn 5,  Seong-Jun Kim 5,  Kun-Soo Kim 2,  Jong-Won Oh 6
Affiliations

Affiliations

  • 1 Department of Biotechnology, Yonsei University, Seoul, 03722, Korea.
  • 2 Department of Life Science, Sogang University, Seoul, 04107, Korea.
  • 3 Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.
  • 4 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.
  • 5 Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea.
  • 6 Department of Biotechnology, Yonsei University, Seoul, 03722, Korea. jwoh@yonsei.ac.kr.
PMID: 29686409 DOI: 10.1038/s41467-018-04075-1
Abstract

The recognition of pathogen-derived ligands by Pattern Recognition Receptors activates the innate immune response, but the potential interaction of quorum-sensing (QS) signaling molecules with host anti-viral defenses remains largely unknown. Here we show that the Vibrio vulnificus QS molecule cyclo(Phe-Pro) (cFP) inhibits interferon (IFN)-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Binding of cFP to the RIG-I 2CARD domain induces a conformational change in RIG-I, preventing the TRIM25-mediated ubiquitination to abrogate IFN production. cFP enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses, each known to be sensed by RIG-I but did not affect the melanoma-differentiation-associated gene 5 (MDA5)-recognition of norovirus. Our results reveal an inter-kingdom network between bacteria, viruses and host that dysregulates host innate responses via a microbial quorum-sensing molecule modulating the response to viral Infection.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z